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  typical Examples of Successful PROJECTS  
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Integrated Drug Discovery

typical projects | chemistry | CADD | biology | ADMET & PK | physical sciences 		 

Typical Fee-for-Service Projects

The following are examples of a selection of projects successfully completed by Argenta for clients:

Target to Development Candidate: Kinase
Starting Points Virtual screening, knowledge-based design and HTS (provided by client)
Objective Development candidate and back-up series
Timescale 27 months
Resource Assigned 10 – 13 FTEs (CADD, medicinal chemistry, biochemistry, in vitro and in vivo PK)
Technologies Applied CADD – virtual screening, chemistry (knowledge-based design, medicinal and synthetic chemistry), analytics, biochemistry (primary and functional assay development and in vitro screening), in vitro ADME and in vivo PK
Results Series 1 – Candidate nomination
Series 2 – Back-up candidate opportunities

 

Target to Candidate: Nuclear receptor
Starting Points Target and known ligands
Objective Clinical candidate
Timescale 27 months
Resource Assigned Chemistry - 4.5 FTE, Biochemistry (including eADMET) 2 FTE, CADD & Analytics 0.5 FTE
Technologies Applied Cloning and expression, binding assay development, functional assay development, selectivity assay development, eADMET screening, metabolite identification, bioanalysis, array and singles synthesis, chiral chemistry
Results Potent series identified, final optimisation in progress. 3 patents filed

 

Target to Clinical Candidate: GPCR
Starting Point Hit series (provided by client)
Objective Development candidate and structurally distinct back-up candidate
Timescale 24 months
Resource Assigned 6 – 8 FTEs (medicinal chemistry, biochemistry, in vitro and in vivo PK)
Technologies Applied Chemistry (knowledge-based design, medicinal and synthetic chemistry), analytics, biochemistry (assay development - three binding assays and a functional assay and in vitro screening), in vitro ADME and in vivo PK
Results Development candidate (undergoing clinical evaluation)

For more information on how we can assist you in your discovery efforts please contact us.

 
   
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Argenta Discovery 2009 Limited is a company incorporated and registered in England with registered number 06920289 whose registered office and principal place of business is at 8/9 Spire Green Centre, Flex Meadow, Harlow, CM19 5TR, United Kingdom and whose VAT registration number is GB 977 4737 57.