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  typical Examples of Successful PROJECTS  
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Integrated Drug Discovery

typical projects | chemistry | CADD | biology | ADMET & PK | physical sciences 		 

Typical Fee-for-Service Projects

The following are examples of a selection of projects successfully completed by Argenta for clients:

Lead to Candidate: 7TM receptor
Start Point Target protein and assay, 1 lead series
Objective 1 development series and 1 backup series
Timescale 12 months
Resource Assigned Chemistry - 3 FTE, Biochemistry 0.5 FTE, CADD & Analytics 1 FTE
Technologies Applied CADD – virtual library preparation, combinatorial and classical chemistry, primary and functional assay development, compound screening
Results 1 development series, 2-3 backup series
Clinical candidate selected by client

 

Target to candidate: Nuclear receptor
Start Point Target and known ligands
Objective Clinical candidate
Timescale 27 months
Resource Assigned Chemistry - 4.5 FTE, Biochemistry (including eADMET) 2 FTE, CADD & Analytics 0.5 FTE
Technologies Applied Cloning and expressing, binding assay development, functional assay development, selectivity assay development, eADMET screening, metabolite identification, bioanalysis, array and singles synthesis, chiral chemistry
Results Potent series identified, final optimisation in progress. 3 patents filed

 

Hit to Lead: Chemokine receptor
Start Point Five hit series from HTS
Objective Lead Status to client specification
Timescale 6 months
Resource Assigned Chemistry - 5 FTE, Biochemistry (including eADMET) 1.5 FTE, Analytics 0.5 FTE
Technologies Applied Array chemistry, microwave chemistry, receptor binding assay development, full PK and physicochemical service provision
Results Proven SAR, improved potency and CYP450 profile
Project progressed to next stage by client

For more information on how we can assist you in your discovery efforts please contact us.

 
   
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Argenta Discovery Limited is a company incorporated and registered in England with registered number 3671653 whose registered office and principal place of business is at 8/9 Spire Green Centre, Flex Meadow, Harlow, CM19 5TR, United Kingdom and whose VAT registration number is GB 848 2268 02.