News, Events and Publications

Recent Scientific Papers and Patents

Scientific Papers

• Identification and Hit-to-Lead Exploration of a Novel Series of Histamine H4 Receptor Inverse Agonists. BioOrg. Med. Chem. Lett., 2010, 20, in press.
• Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites. J. Med. Chem., 52, 7706–7723, 2009.
• 5-Aminopyrimidin-2-ylnitriles as Cathepsin K inhibitors. BioOrg. Med. Chem. Lett., 19, 1658-1661, 2009.
• BGC20-1531, a novel, potent and selective prostanoid EP4 receptor antagonist; a putative new treatment for migraine headache. Br. J. Pharmacol., 156, 316-327, 2009.
• Muscarinic antagonist beta-adrenergic agonist (MABA) dual pharmacology molecules as bronchodilators: A patent review. Expert Opin. Ther. Patents, 19, 1-12, 2009.

Patents

• 2-hydroxy-ethanesulfonate salt. WO2010/019099.
• Pharmaceutical product comprising a muscarinic receptor antagonist and a beta-2-adrenoceptor agonist. WO2010/019098.
• Pharmaceutical product comprising a muscarinic receptor antagonist and a second active ingredient. WO2010/019097.
• Heterocyclic compounds used in the treatment of diseases where enhanced M3 receptor activation is implicated. WO2010/018352.
• Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors. WO2010/015792.
• Bicyclic heterocycles as Mek kinase inhibitors. WO2010/003025.
• Isoindolone derivatives as Mek kinase inhibitors and methods of use. WO2010/003022.