News, Events and Publications

Recent Scientific Papers and Patents

Scientific Papers

2008

• Towards improving data analysis and compound selection in structure-based virtual screening. Drug Discov. Today, 13, 219-226, 2008.
• Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorg. Med. Chem. Lett.,18, 1312-1317, 2008.

2007

• 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors as therapeutic agents. Expert Opin. Ther. Patents, 17, 1407-1422, 2007.
• In silico ADMET tools: The dawn of a new generation? Expert Opin. Drug Discov., 2, 1423-1429, 2007.
• Computational Prediction of Aqueous Solubility, Oral Bioavailability, P450 Activity and hERG Channel Blockade. In: Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions, Stroud, R.M. and Finer-Moore, J. (Eds.), RSC Publishing, pp. 207-222, 2007.
• Novel 5,6-dihydropyrazolo[3,4-E][1,4]diazepin-4 (1H)-one derivatives for the treatment of asthma and chronic obstructive pulmonary disease (AstraZeneca: WO2007/040435). Expert Opin. Ther. Patents 17, 1183-1189, 2007.
• 2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists. Bioorg. Med. Chem. Lett. 17, 5704-5708, 2007.
• Discovery and optimisation of novel, nonsteroidal glucocorticoid receptor antagonists. Bioorg. Med. Chem. Lett. 17, 4901-4905, 2007.
• Histone deacetylase inhibitors: an analysis of recent patenting activity. Expert Opin. Ther. Patents 17, 745-765, 2007.
• Emerging trends in the therapy of COPD: novel anti-inflammatory agents in clinical development. Drug Discov. Today 12, 479-486, 2007.
• Emerging trends in the therapy of COPD: bronchodilators as mono- and combination therapies. Drug Discov. Today 12, 472-478, 2007.
• Quinazoline and benzimidazole MCH-1R antagonists. Bioorg. Med. Chem. Lett. 17, 1403-1407, 2007.
• Identification and optimisation of a series of substituted 5-(1 H -pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. Bioorg. Med. Chem. Lett. 17, 370-375, 2007.
• Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. Bioorg. Med. Chem. Lett. 17, 363-369, 2007.
• Outsourcing lead optimisation: constant change is here to stay. Drug Discov. Today 12, 62-70, 2007.

Patents

2008

• Chemical compounds. WO/2008/017827
• Hept-7-ylamine derivatives and their use. WO/2008/017824

2007

• 2-Oxo-2H-chromene compounds. WO2007/144625
• Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors. WO2007/129060
• Multimers of heterocyclic compounds and their use. WO2007/107706
• Cyclic amine derivatives and their uses. WO2007/068929
• Tumor necrosis factor 1 receptor antagonists for treating respiratory diseases. WO2007/049017
• 3-Aminoindole compounds as CRTh2 receptor ligands. WO2007/045867
• Compounds containing more than one human neutrophil elastase inhibiting moiety for use in the treatment of respiratory diseases. WO2007/042815
• Quinolines and their therapeutic use. WO2007/036743
• Indolizine derivatives as ligands of the CRTh2 receptor. WO2007/031747
• Thiazole compounds and their use as PGD2 antagonists. WO2007/028999
• Bicyclo[2.2.]hept-7-ylamine derivatives and their uses. WO2007/017670
• Azole and thiazole derivatives and their use. WO2007/017669